Basic Information
VIS ID
TVIS44000197
Fusion event
HTLV-1-ZBTB7C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45590052/48063681 (Hg38)
End
45590052/48063681 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZBTB7C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p
Nearest miRNA
hsa-mir-1-2/Upstream/683116; hsa-mir-122/Downstream/606919;
Nearest TSS
ENST00000575820/Upstream/132535; ENST00000591412/Downstream/73680;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/33839, chr18-CpG: 116/Downstream/72262
Nearest cancer related gene
ZBTB7C(TSG, No orient, 0)
Upstream sequence
ggaaaaaggagagaaaggaggagaggtgaCAGTATGTGTTATAGAAATAAAAGAATGGCCAATTGCCATGGCCAGCTTTCTCAACAAGAAGTGGTCTAGG
Downstream sequence
TTTTCAACAGATGCTCACTGGGCAGAGATGTCTTGAGAGGTGTATGGGGCTATGGGGATTATGTGGTTAATCCTAATTTTGCAGATGTTGAGAAAACTAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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