Basic Information
VIS ID
TVIS44000210
Fusion event
HTLV-1-CRADD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
94284619/93890843 (Hg38)
End
94284619/93890843 (Hg38)
Orient
-
Location type
Intronic
Target gene
CRADD
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-1246 ; hsa-mir-8076 ; hsa-mir-5011-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-let-7i/Upstream/7145694; hsa-mir-1178/Downstream/670946;
Nearest TSS
ENST00000382841/Upstream/42183; ENST00000604017/Downstream/52760;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/212964, chr12-CpG: 31/Downstream/211214
Nearby gene
CRADD(+40088) ;
Upstream sequence
gcttgttttttctttctttctttttttttttttgagacagagtctccctctgtcacccaggctagagtgcagtggcactatttggctcactgcagcctcc
Downstream sequence
acctcctgtgattctcatgcttcagcctcccaagtaattgggactacaggcacgtgccacacctgactaattttttggtattcttagtagagatggggtt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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