Basic Information
VIS ID
TVIS44000213
Fusion event
HTLV-1-TNS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
218724021/217859298 (Hg38)
End
218724021/217859298 (Hg38)
Orient
-
Location type
Intronic
Target gene
TNS1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-4446-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-4279 ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-627-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3679-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-22-5p ; hsa-mir-6887-3p ; hsa-mir-3691-3p ; hsa-mir-5584-3p ; hsa-mir-148a-5p ; hsa-mir-942-5p ; hsa-mir-6783-5p ; hsa-mir-8055 ; hsa-mir-6739-3p ; hsa-mir-375 ; hsa-mir-1304-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-6868-3p ; hsa-mir-8068 ; hsa-mir-4326 ; hsa-mir-5087 ; hsa-mir-4751 ; hsa-mir-5004-5p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-548j-5p ; hsa-mir-142-5p ; hsa-mir-33a-5p ; hsa-mir-33b-5p ; hsa-mir-340-5p ; hsa-mir-4666a-3p ; hsa-mir-4729 ; hsa-mir-5590-3p ; hsa-mir-5700 ; hsa-mir-586
Nearest miRNA
hsa-mir-10b/Upstream/4101139; hsa-mir-1244-1/Downstream/41215;
Nearest TSS
ENST00000437798/Upstream/665; ENST00000450996/Downstream/26512;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/102523, chr2-CpG: 30/Downstream/119360
Upstream sequence
AAGGGCCAGAGAGGGAGGGGAGAGAGGTCCTATGAGGGTATTGAGATTTATTTCCCCAAATTTTCCACATTTTTTTTCCATTCTCAGCAAATGGAAGGCA
Downstream sequence
GAACAGATGACAACAATTTTCCAGCTGCTGAACAATAAGGTGGAAATCTTTTTTTCCCTCTCTCTCCCCCTTTCCCCTCCACAGGGCAGAGTCCAGGAGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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