VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000221

Fusion event

HTLV-1-MCUR1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr6

Cytoband

p23

Reference genome

GRCh37/hg19

Start

13814704/13814472 (Hg38)

End

13814704/13814472 (Hg38)

Orient

Location type

UTR5

Fragile sites / regions

FRA6A

Target gene

MCUR1

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-484 ; hsa-mir-7156-3p ; hsa-mir-1229-3p ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-4733-3p ; hsa-mir-1226-3p ; hsa-mir-1322 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-1303 ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-4653-3p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6849-3p ; hsa-mir-1273e ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6499-3p ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-4468 ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4257 ; hsa-mir-4756-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p

Nearest miRNA

hsa-mir-3691/Upstream/3374678; hsa-mir-10398/Downstream/2327084;

Nearest TSS

ENST00000381078/Upstream/13127; ENST00000607518/Downstream/96;

Nearest CpG islands

chr6-CpG: 121/Target, None/Upstream, None/Downstream

Upstream sequence

CCGCTGGCGGCCGGGCAGGCGCTGGGTCCTCTGGCCGCCGACCGAGCCGCAGTCCATCCCCGAGCAGTTCACTGGCCCGGGCGCGCGCTCATGCCTCTCG

Downstream sequence

CTTTTGGCGCCGGCCACGCGCGGTCCAGGCCCAGAGTCCGACAGCGGGAGCGAGCGTGGGCCACAGCGCAGGACCGCCCTTTCCTgccgggcgcgcgggc

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.