Basic Information
VIS ID
TVIS44000222
Fusion event
HTLV-1-ZNF425 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
148817747/149120655 (Hg38)
End
148817747/149120655 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ZNF425
miRNAs that regulate target gene
hsa-mir-4529-3p ; hsa-mir-8058 ; hsa-mir-5009-5p ; hsa-mir-1269a ; hsa-mir-1269b ; hsa-mir-4709-3p ; hsa-mir-6503-3p ; hsa-mir-1306-3p
Nearest miRNA
hsa-mir-10399/Upstream/1742534; hsa-mir-153-2/Downstream/2117766;
Nearest TSS
ENST00000635602/Upstream/7201; ENST00000485111/Downstream/5651;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/15673, chr7-CpG: 97/Downstream/5467
Upstream sequence
ctataagattataatattgcatttttactggacgtttatgtttagatacacaaatacttactattgtgttacaactgcctacggtattcagtacagtaac
Downstream sequence
atgctatacaagtttgtagcctaggagaaataagctataccatctaggtttttggaagcacactctgatgtttgcacaaccacaaaattgcctaacaatg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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