Basic Information
VIS ID
TVIS44000225
Fusion event
HTLV-1-AGRN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
959608/1024228 (Hg38)
End
959608/1024228 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
AGRN
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-mir-4758-3p ; hsa-mir-4632-3p ; hsa-mir-500b-3p ; hsa-mir-4323
Nearest miRNA
hsa-mir-12136/Upstream/391543; hsa-mir-101-1/Downstream/142876;
Nearest TSS
ENST00000473358/Upstream/4105; ENST00000477585/Downstream/9878;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3265, chr1-CpG: 54/Downstream/4187
Nearest cancer related gene
AGRN(OG, No orient, 0)
Upstream sequence
TGGGACATGTGGAGCTCTGCTGTGGAAGTAGACCAGGGATATCTCGGGTGGCTGGGGTCCCTGGCTGCCGGGACAGGGTAAATGCCTCCCAGAAGCCTGG
Downstream sequence
GGTGAGCCCTGAGGGACAAGGTCTCTGGAGCCAGTCTGGCTGGAGAAGGGACAATTCTGTGTGCCCACCCCTCCCCTCACACTGGGTGGTGTGGGAGGTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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