Basic Information
VIS ID
TVIS44000226
Fusion event
HTLV-1-PIP4K2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
22989248/22700319 (Hg38)
End
22989248/22700319 (Hg38)
Orient
+
Location type
Intronic
Target gene
PIP4K2A
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-122-5p ; hsa-mir-30b-5p ; hsa-mir-101-3p ; hsa-mir-193b-3p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-6754-5p ; hsa-mir-4684-3p ; hsa-mir-218-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-4763-3p ; hsa-mir-4683 ; hsa-mir-1207-5p ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-6760-5p ; hsa-mir-548al ; hsa-mir-4445-3p ; hsa-mir-5701 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-4668-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-548c-3p ; hsa-mir-5687 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1265/Upstream/1203678; hsa-mir-107/Downstream/1575366;
Nearest TSS
ENST00000439456/Upstream/8489; ENST00000465729/Downstream/13789;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/222198, chr10-CpG: 91/Downstream/12907
Upstream sequence
TCAAGGAAAACTGCTTATGGACCAATTCATACATCCTACACCACATTCCCGATAGCACCGATCTCATACAAGTGAATCTGCATTATAGAAGCATGTATGT
Downstream sequence
AGCAGCAGCAAAGACTGCACAACGGTGCATTTTCTAAAGCAGATTCAAATCTATAAGGGGACTTTATAAACCCCACTTTCTTTTCTTCTGTCCAGACTGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate