Basic Information
VIS ID
TVIS44000232
Fusion event
HTLV-1-TMEM94 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
73440132/75444051 (Hg38)
End
73440132/75444051 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM94
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-24-3p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-15a-3p ; hsa-mir-4308 ; hsa-mir-4292 ; hsa-mir-3657 ; hsa-mir-6791-5p ; hsa-mir-7855-5p ; hsa-mir-4710 ; hsa-mir-4316 ; hsa-mir-4792 ; hsa-mir-6089 ; hsa-mir-5008-5p ; hsa-mir-4299
Nearest miRNA
hsa-mir-10226/Upstream/37889; hsa-mir-1250/Downstream/54497;
Nearest TSS
ENST00000595228/Upstream/2892; ENST00000581834/Downstream/12413;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/38144, chr17-CpG: 22/Downstream/57967
Nearby gene
TMEM94(No orient, 12532)
Upstream sequence
cctggtgttaggagctattaaactagtacaacaggtgttgatgatggccgggacccaggttgtagagttggaaatgacagaagcggacatattagggtta
Downstream sequence
taattggagttagaacccacagaacttgctgacagatgaatatggtaagggaggcaagggaagaaatcaaacatgccaggttttggctgaagcaactgga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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