Basic Information
VIS ID
TVIS44000233
Fusion event
HTLV-1-VPS4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
61087890/63420657 (Hg38)
End
61087890/63420657 (Hg38)
Orient
+
Location type
Intronic
Target gene
VPS4B
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-32-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-125b-5p ; hsa-mir-526b-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-5186 ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-877-3p ; hsa-mir-935 ; hsa-mir-5094 ; hsa-mir-548m ; hsa-mir-367-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-363-3p ; hsa-mir-92b-3p ; hsa-mir-216a-3p ; hsa-mir-3681-3p ; hsa-mir-488-3p
Nearest miRNA
hsa-mir-1-2/Upstream/4969499; hsa-mir-5011/Downstream/3660927;
Nearest TSS
ENST00000575820/Upstream/15943; ENST00000424602/Downstream/1733;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/52834, chr18-CpG: 84/Downstream/1372
Upstream sequence
GCCAACGATGACAAGATGGGCACTTCAGAAGAGTCACCTTTAATACTCAAGGGAAAAATACTTTTACCAAATGACCAACGCTTTTTCCAAATACGTTTAC
Downstream sequence
CAAAAAGAACCTTTCCAAATAGGACTACAAAAAGCTACAAAAAACTCAAGTGAAGATTGCTGAATCTTAGTTTAATACAACCTTGGTGAAAAAGATAGTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate