Basic Information
VIS ID
TVIS44000239
Fusion event
HTLV-1-INPP4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
143693527/142772374 (Hg38)
End
143693527/142772374 (Hg38)
Orient
+
Location type
Intronic
Target gene
INPP4B
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-mir-181a-5p ; hsa-mir-765
Nearest miRNA
hsa-mir-12113/Upstream/17265067; hsa-mir-1305/Downstream/571086;
Nearest TSS
ENST00000502981/Upstream/4405; ENST00000510377/Downstream/73916;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1135204, chr4-CpG: 111/Downstream/73413
Nearest cancer related gene
INPP4B(TSG, No orient, 0)
Upstream sequence
ggaggcctgtccttaaggagcttacagcagagtgtgtggaggcGTGTGTCTCTGGGGTGGGAGTGAGGCATCAATAAGTAAAATACACAGCAGAAGGAAA
Downstream sequence
TAGCTGTGAAAGAGAATGAAGCAAAGTGGAGTTGAAGTTGTGATTAATTCCAACTGAACAATCTGTGAACAATCTGTTTCTCCCAGACTATCGCATTTCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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