Basic Information
VIS ID
TVIS44000241
Fusion event
HTLV-1-PTGER4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
40692988/40692886 (Hg38)
End
40692988/40692886 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA5A
Target gene
PTGER4
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-10397/Upstream/2135325; hsa-mir-103a-1/Downstream/13258618;
Nearest TSS
ENST00000502646/Upstream/11184; ENST00000254691/Downstream/63022;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/10907, chr5-CpG: 68/Downstream/62549
Upstream sequence
GTCTCACTAAAGCATGAAATGTGAATTTTTATTGTTGTACATACGATTTAAGGTATTTAAAGTATTTTCTTCTCTGTGAGAAGGTTTATTGTTAATACAA
Downstream sequence
GGTATAATAAAATTATCGCAACCCCTCTCCTTCCAGTATAACCAGCTGAAGTTGCAGATGTTAGATATTTTTCATAAACAAGTTCGAGTCAAAGTTGAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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