Basic Information
VIS ID
TVIS44000244
Fusion event
HTLV-1-TAX1BP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
27825118/27785499 (Hg38)
End
27825118/27785499 (Hg38)
Orient
+
Location type
Intronic
Target gene
TAX1BP1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-500a-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-143-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-545-5p ; hsa-mir-2681-5p ; hsa-mir-4422 ; hsa-mir-6801-5p ; hsa-mir-7844-5p ; hsa-mir-6797-3p ; hsa-mir-6076
Nearest miRNA
hsa-mir-1183/Upstream/615936; hsa-mir-10399/Downstream/1895235;
Nearest TSS
ENST00000635602/Upstream/15821; ENST00000457186/Downstream/7639;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/44517, chr7-CpG: 144/Downstream/393912
Upstream sequence
TTAAAGGACAAACTCAAGAAGGCACAACATGAAAGAGAACAACTTGAATGTCAGTTGAAGACAGAGAAGGATGAAAAGGAACTTTATAAGGTAATTTATT
Downstream sequence
TTTTACCATATCTAttgcctgttgcttcaaaagaaatgaccccagaacttaggggctgtaggtcagcaatttaggagcagcttagctgagtggttctggc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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