Basic Information
VIS ID
TVIS44000273
Fusion event
HTLV-1-PTCHD4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
47890170/47922434 (Hg38)
End
47890170/47922434 (Hg38)
Orient
-
Location type
Intronic
Target gene
PTCHD4
miRNAs that regulate target gene
hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-1273e ; hsa-mir-3622b-5p ; hsa-mir-549a ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p
Nearest miRNA
hsa-mir-10398/Upstream/2724664; hsa-mir-10524/Downstream/4221915;
Nearest TSS
ENST00000381078/Upstream/127685; ENST00000335783/Downstream/146219;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/444079, chr6-CpG: 44/Downstream/145967
Upstream sequence
TCACTCCTCTCTGACTCTTTCCTTTTATCCCATCTCCATTCCTTTCTCTCTTCACCACCACCTTCCCATTGTGGATATGAGTGTCTGGTTTCCTTTACca
Downstream sequence
gcccccctgccggcccaactggctccttcgtgggaattagaaagaggctattatttaaatggctgcagttccatcagttcacaacttggcgagaggGCTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate