Basic Information
VIS ID
TVIS44000287
Fusion event
HTLV-1-CASC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
119858951/118099440 (Hg38)
End
119858951/118099440 (Hg38)
Orient
+
Location type
ncRNA_exonic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CASC2
miRNAs that regulate target gene
hsa-mir-21-5p
Nearest miRNA
hsa-mir-107/Upstream/931666; hsa-mir-202/Downstream/1278532;
Nearest TSS
ENST00000439456/Upstream/49826; ENST00000614455/Downstream/104849;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/52407, chr10-CpG: 33/Downstream/242612
Nearest cancer related gene
CASC2(TSG, No orient, 0)
Upstream sequence
gattttcttattatcccgattttacaaatgagcaaacagaggcacaagcaggttaagaaacctccccaaggttaaacagtgagaaacagcaaagatttga
Downstream sequence
acAGTGAGAAACAGCAAAGATTTGAAACAGCAAAGATTTGAACCTATTGTTCGGGAGTCCATGCTGTTACTCATTTCTTTATGCTGCCATAATCTAATAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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