Basic Information
VIS ID
TVIS44000289
Fusion event
HTLV-1-FAM234B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
13198422/13045488 (Hg38)
End
13198422/13045488 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM234B
miRNAs that regulate target gene
hsa-mir-450b-5p ; hsa-mir-3121-5p ; hsa-mir-6734-3p ; hsa-mir-6814-5p ; hsa-mir-532-5p ; hsa-mir-4684-5p ; hsa-mir-4662a-5p ; hsa-mir-3613-3p ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p ; hsa-mir-548c-3p ; hsa-mir-550b-2-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1227-3p ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-1273a ; hsa-mir-1273c ; hsa-mir-661 ; hsa-mir-4252 ; hsa-mir-4537 ; hsa-mir-5186 ; hsa-mir-4486 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-1273e ; hsa-mir-1323 ; hsa-mir-335-5p ; hsa-mir-3664-5p ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-548o-3p ; hsa-mir-548p ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6840-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/129570; hsa-let-7i/Downstream/4627811;
Nearest TSS
ENST00000382841/Upstream/1107; ENST00000535974/Downstream/16227;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/641, chr12-CpG: 61/Downstream/55627
Upstream sequence
ATTTGCTGATAATTTGTATTAGAGGGAAAAGCAGTTGCTTTCATAGCTATCTCTAGAGAGGGCTATTTGGGTTTTGGTTGGATAGCTAGTTTGAGCTTGC
Downstream sequence
AGGGGGATTacagggtccttgttctcaaggagcttccagtATGCTACCCTGAAGCGAACCTTGCCATTTGGATGACGCTAGGTTGGATATTAATTTGCGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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