Basic Information
VIS ID
TVIS44000313
Fusion event
HTLV-1-ADGRB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
69684104/68974212 (Hg38)
End
69684104/68974212 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRB3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/11584000; hsa-mir-10524/Downstream/2402748;
Nearest TSS
ENST00000381078/Upstream/335536; ENST00000604969/Downstream/258194;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/339058, chr6-CpG: 53/Downstream/822188
Upstream sequence
atGTGCCTTTTTGTTTGTTGGAAGTCACTTTTTTGTATAACATCCtaaaatattataaatatttttattGATATGCCTGAATATGTTCAACTTGTAGGCA
Downstream sequence
AATCCAAATGACCTCTATAAATAGTCTACACAGTAAGCAGTTCAAAAAGAAATTACAATTCTGTAAATACTTTGTAGATACTAAAAGGAAATCTGATGGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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