VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000317

Fusion event

HTLV-1-ARHGEF39 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr9

Cytoband

p13.3

Reference genome

GRCh37/hg19

Start

35659684/35659687 (Hg38)

End

35659684/35659687 (Hg38)

Orient

Location type

UTR3

Target gene

ARHGEF39

miRNAs that regulate target gene

hsa-mir-640 ; hsa-mir-6815-3p ; hsa-mir-212-5p ; hsa-mir-1224-3p ; hsa-mir-125a-3p ; hsa-mir-6813-3p ; hsa-mir-4284 ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-149-5p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-6890-3p ; hsa-mir-5089-5p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-5697 ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-582-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-1305 ; hsa-mir-208a-5p ; hsa-mir-208b-5p ; hsa-mir-3157-5p ; hsa-mir-335-3p ; hsa-mir-383-3p ; hsa-mir-449b-3p ; hsa-mir-4691-3p ; hsa-mir-5095 ; hsa-mir-512-5p ; hsa-mir-552-3p ; hsa-mir-607 ; hsa-mir-6504-3p ; hsa-mir-6715a-3p ; hsa-mir-6715b-3p ; hsa-mir-6807-5p ; hsa-mir-7151-3p

Nearest miRNA

hsa-mir-101-2/Upstream/51528; hsa-let-7a-1/Downstream/50989;

Nearest TSS

ENST00000422679/Upstream/1370; ENST00000493245/Downstream/2957;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/907, chr9-CpG: 40/Downstream/5375

Upstream sequence

agggcattgctttaagagcactacgtgttcaggaaacaaccagagaaaaccaccgtcaatgagcactgactgtaaagactgacgttaataaaccagaaaa

Downstream sequence

aactcaggaaagtgggtgagggtgtgaccattgccttcaaattcctgaggggctgtcaccttgaggagacattattttggaaggctccagtaagcactat

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.