Basic Information
VIS ID
TVIS44000320
Fusion event
HTLV-1-CAMTA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.23
Reference genome
GRCh37/hg19
Start
7452994/7392934 (Hg38)
End
7452994/7392934 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
CAMTA1
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-155-5p ; hsa-mir-218-5p ; hsa-mir-34a-5p ; hsa-mir-96-5p ; hsa-mir-124-3p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p
Nearest miRNA
hsa-mir-12136/Upstream/963038; hsa-mir-101-1/Downstream/1473568;
Nearest TSS
ENST00000473358/Upstream/3180; ENST00000476864/Downstream/48620;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/330267, chr1-CpG: 111/Downstream/270406
Nearest cancer related gene
CAMTA1(TSG, No orient, 0)
Upstream sequence
ctgagctccagcctggacgacagagactctgtctcgatcaatcaatcaatcaatcaatcaatctataagctgagtgtggtggttagtgcacacctgtagt
Downstream sequence
cccagctacttgggaagctgaggcgagaggatcatttgaggtcaggagttcgaggctgcagtgagctatgatcgcgccactgcgttccagcctggatgac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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