Basic Information
VIS ID
TVIS44000332
Fusion event
HTLV-1-DUSP16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12680541/12527607 (Hg38)
End
12680541/12527607 (Hg38)
Orient
-
Location type
Intronic
Target gene
DUSP16
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-6818-5p ; hsa-mir-580-3p ; hsa-mir-4693-5p ; hsa-mir-4738-3p ; hsa-mir-892a ; hsa-mir-4318 ; hsa-mir-606
Nearest miRNA
hsa-mir-1244-3/Upstream/415571; hsa-let-7i/Downstream/237042;
Nearest TSS
ENST00000382841/Upstream/21420; ENST00000540224/Downstream/33279;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/170113, chr12-CpG: 111/Downstream/34092
Upstream sequence
AAGAACTTggtgcggcaaaccaccatggcatgtgtatacctatgaaacaaacctgcatgttctgcacatgtaccccagaacttaaaagtataataTATAC
Downstream sequence
TTTATAATATGTACTTTTATTTATAAAAGTATAAAACAAAGTAAAACTACAAACTTAATGTGCTTTTTAGCTGCCTATTAATGTCtgatcatatttcctt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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