Basic Information
VIS ID
TVIS44000341
Fusion event
HTLV-1-ZFPM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
88530467/88464059 (Hg38)
End
88530467/88464059 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZFPM1
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-200c-3p ; hsa-mir-142-3p ; hsa-mir-5682 ; hsa-mir-585-5p ; hsa-mir-4764-3p ; hsa-mir-601 ; hsa-mir-423-3p ; hsa-mir-500b-3p ; hsa-mir-6871-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-4482-5p ; hsa-mir-3130-5p
Nearest miRNA
hsa-mir-11401/Upstream/610095; hsa-mir-4722/Downstream/4859;
Nearest TSS
ENST00000527434/Upstream/10432; ENST00000569435/Downstream/66994;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/7953, chr16-CpG: 40/Downstream/3930
Upstream sequence
GCAGGGCCAGCCCTGGGCACTTCCAGGAAGTCCCAGACCATGGGATGGGGCTCCAGCCAGCCAGGAGCCCTTGATCGAGGTGTTTGTTCTATACCCCGTG
Downstream sequence
GTCCATCGGTCAATCCTTGGGGGCTGGAAGGAATGGATTGGAGGCTCCTTCTTCCCAGTGGACAGAGGTGCTCTGTTTAGGGCCTGGGTGCCGCGTCTCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate