Basic Information
VIS ID
TVIS44000342
Fusion event
HTLV-1-NEDD4L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
56050286/58383054 (Hg38)
End
56050286/58383054 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
NEDD4L
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-423-5p ; hsa-mir-7855-5p ; hsa-mir-6807-5p ; hsa-mir-7843-3p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-5186 ; hsa-mir-4786-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6504-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-93-3p ; hsa-mir-30a-5p ; hsa-mir-376c-3p
Nearest miRNA
hsa-mir-1-2/Upstream/2903756; hsa-mir-122/Downstream/68020;
Nearest TSS
ENST00000575820/Upstream/9884; ENST00000588712/Downstream/4657;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/126218, chr18-CpG: 92/Downstream/287925
Nearest cancer related gene
NEDD4L(TSG, No orient, 0)
Upstream sequence
TAAATGAATAGCAGAGGAAAAAATGTTGCTCTTCATTATTGCTAATATATGAAGAATAATTAAAAGTCATAAATAACCATAAAACAATTTGCCTTTAATG
Downstream sequence
ATAGCATCTTTAACTGTGTAACATCCTAGCAAAAAAGCCTCATTGGACATTCTCTTGTGCACAGAGCCCATTTGCCGGGAAATATTTCTGAATACATGTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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