VISDB Viral Integration Site DataBase

VIS ID

TVIS44000348

Fusion event

HTLV-1-MAT2A integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr2

Cytoband

p11.2

Reference genome

Start

End

85767724/85540601 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2L

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-193b-3p ; hsa-mir-26b-5p ; hsa-mir-196b-5p ; hsa-mir-324-3p ; hsa-mir-326 ; hsa-mir-106b-5p ; hsa-mir-186-5p ; hsa-mir-125a-5p ; hsa-mir-101-5p ; hsa-mir-340-5p ; hsa-mir-1298-3p ; hsa-mir-3126-3p ; hsa-mir-548at-5p ; hsa-mir-26a-5p ; hsa-mir-424-3p ; hsa-mir-876-5p ; hsa-mir-1297 ; hsa-mir-3167 ; hsa-mir-4465 ; hsa-mir-4691-5p ; hsa-mir-5193 ; hsa-mir-5697 ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-6864-5p ; hsa-mir-7515 ; hsa-mir-548c-3p ; hsa-mir-4258 ; hsa-mir-29b-1-5p ; hsa-mir-548e-5p ; hsa-mir-30b-3p ; hsa-mir-143-5p ; hsa-mir-765 ; hsa-mir-3192-5p ; hsa-mir-4302 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3911 ; hsa-mir-3944-5p ; hsa-mir-3689c ; hsa-mir-4653-3p ; hsa-mir-6499-3p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-7106-5p ; hsa-mir-1273h-5p ; hsa-mir-7847-3p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-1276 ; hsa-mir-4694-3p ; hsa-mir-5680 ; hsa-mir-492 ; hsa-mir-631 ; hsa-mir-2052 ; hsa-mir-4292 ; hsa-mir-3661 ; hsa-mir-4535 ; hsa-mir-4776-5p ; hsa-mir-548as-3p ; hsa-mir-6732-3p ; hsa-mir-6791-5p ; hsa-mir-484 ; hsa-mir-510-5p ; hsa-mir-3155a ; hsa-mir-3160-5p ; hsa-mir-3155b ; hsa-mir-21-3p ; hsa-mir-5701 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-512-5p ; hsa-mir-504-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6894-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4732-3p ; hsa-mir-6783-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-3936 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-3179 ; hsa-mir-660-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-510-3p ; hsa-mir-659-5p ; hsa-mir-6861-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-3133 ; hsa-mir-4774-5p ; hsa-mir-4490 ; hsa-mir-4668-5p ; hsa-mir-146b-3p

Nearest miRNA

hsa-mir-1285-2/Upstream/5674018; hsa-mir-10b/Downstream/242999;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/741, chr2-CpG: 37/Downstream/20687

Nearest cancer related gene

MAT2A(TSG, No orient, 0)

Upstream sequence

CGGTTATAGAAAATTCAGAAAAACGAACTTGAATTAGGGAGATATTTGTTCTCCCTCCTAACAATAGATGACAAAGCAGGGAGACATGGATTCGGAATAC

Downstream sequence

GTTTGAGCATCTTCTACACTGTTGAGCTTTTGTTTCCTGCGCAACTCCTAACAGCAAAATCAGATAATTGCCATTTTAGTCAGAAAATGCTTTTCATTTA