Basic Information
VIS ID
TVIS44000353
Fusion event
HTLV-1-C21orf91 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
19167042/17794725 (Hg38)
End
19167042/17794725 (Hg38)
Orient
-
Location type
Intronic
Target gene
C21orf91
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-100-5p ; hsa-mir-4662a-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-4480 ; hsa-mir-6513-3p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-mir-1183 ; hsa-mir-595 ; hsa-mir-1911-5p ; hsa-mir-3065-3p ; hsa-mir-624-5p ; hsa-mir-634 ; hsa-mir-561-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-4698 ; hsa-mir-8485 ; hsa-mir-4694-3p ; hsa-mir-377-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-224-5p ; hsa-mir-2682-3p ; hsa-mir-3152-5p ; hsa-mir-374c-5p ; hsa-mir-4263 ; hsa-mir-429 ; hsa-mir-4724-5p ; hsa-mir-4799-5p ; hsa-mir-4999-3p ; hsa-mir-576-5p ; hsa-mir-655-3p ; hsa-mir-6781-3p ; hsa-mir-6836-3p ; hsa-mir-7850-5p ; hsa-mir-8084
Nearest miRNA
hsa-let-7c/Upstream/1204400; hsa-mir-155/Downstream/891365;
Nearest TSS
ENST00000624081/Upstream/1237; ENST00000454737/Downstream/14220;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/181346, chr21-CpG: 118/Downstream/24053
Upstream sequence
gtttgaaattgtttataatttaacaaaaaagactaatATCACATGCCTTAAAGAACTGTTTGGGAGGACTCCCACATAGTGCCTGGTGCAATAGTGGGTA
Downstream sequence
GTCAATAAAATGTTAGTAAGAGGTGGTAGTTTCCATTTTCACTTAGAAAAGAAAAATGTggctgggcgcagtggctcacacctgtaatgccagctctttg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate