Basic Information
VIS ID
TVIS44000355
Fusion event
HTLV-1-FAM3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
42728319/41356392 (Hg38)
End
42728319/41356392 (Hg38)
Orient
-
Location type
Intronic
Target gene
FAM3B
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7c/Upstream/188763; hsa-mir-5692b/Downstream/390380;
Nearest TSS
ENST00000624081/Upstream/33572; ENST00000494252/Downstream/5551;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/39234, chr21-CpG: 29/Downstream/63974
Upstream sequence
attgaaaatttacatgtagcatacctaacctaccaaagatgatagtttagcatagcataccttaaacatgctcagaacacttacagttgactgcagttgg
Downstream sequence
gcaaaatcacctaacacaaagcctattttacaataaagtatggagtgtctcatggaatttattgaacactgtactgaaagtgaaacagaatggttgtgtg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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