Basic Information
VIS ID
TVIS44000366
Fusion event
HTLV-1-ADAM19 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
156924481/157497473 (Hg38)
End
156924481/157497473 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAM19
miRNAs that regulate target gene
hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-106a-3p ; hsa-mir-6867-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-4685-3p ; hsa-mir-7111-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6832-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4753-5p ; hsa-mir-27b-5p
Nearest miRNA
hsa-mir-10397/Upstream/2667933; hsa-mir-103a-1/Downstream/2976929;
Nearest TSS
ENST00000502646/Upstream/37144; ENST00000518054/Downstream/5349;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/37041, chr5-CpG: 22/Downstream/76987
Upstream sequence
ATGCTTTagtaatagcagctacttttatgcagctcccacttaagtgtccagtacaaatatgacttcacttagttttcatgacagtcctgtgtgatataat
Downstream sequence
tatcccttctgcagatgataaaatctgtaggcttaaagaggttagacgatgcatccaaagactcatagtaagtggcagaggagccaggCCCACTAATaca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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