Basic Information
VIS ID
TVIS44000377
Fusion event
HTLV-1-PSMA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
42957462/42917863 (Hg38)
End
42957462/42917863 (Hg38)
Orient
-
Location type
Intronic
Target gene
PSMA2
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-29c-3p ; hsa-mir-186-5p ; hsa-mir-191-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-let-7a-5p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-3668 ; hsa-mir-548aj-5p ; hsa-mir-5680 ; hsa-mir-497-3p ; hsa-mir-651-5p ; hsa-mir-302c-5p ; hsa-mir-616-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-3159 ; hsa-mir-595 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-212-3p
Nearest miRNA
hsa-mir-1183/Upstream/5998431; hsa-mir-10399/Downstream/233032;
Nearest TSS
ENST00000635602/Upstream/5558; ENST00000432845/Downstream/9601;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/5557, chr7-CpG: 50/Downstream/14172
Upstream sequence
AATACTGAGCTAACCTTTAGGGTTAAGATGGCTGTATGAATGGCATCTTCAAGTTCCAGATCTTCATTATATCTGAAGAATTTAAAAAAAATTACTTATA
Downstream sequence
TCATTGTTTATATTCTTTATAACTATTTAAATACAATGACAGCAACAACGTAAGTTTTTAAAACTCTAAACATCTTAAAAATACTAAATTACACATTCTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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