Basic Information
VIS ID
TVIS44000400
Fusion event
HTLV-1-UGGT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
96495983/95843729 (Hg38)
End
96495983/95843729 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
UGGT2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-218-5p ; hsa-mir-1247-3p ; hsa-mir-1976 ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4532 ; hsa-mir-4722-3p ; hsa-mir-484 ; hsa-mir-5571-5p ; hsa-mir-6715b-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6752-3p ; hsa-mir-6778-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6836-3p
Nearest miRNA
hsa-mir-1297/Upstream/3353509; hsa-mir-1267/Downstream/583500;
Nearest TSS
ENST00000623511/Upstream/166571; ENST00000620595/Downstream/16166;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/166037, chr13-CpG: 81/Downstream/209246
Upstream sequence
atttttacttacggcatattagggtttagaggtttttggggtttttttttggcataaggatatctaattgttccagcactgtttgttgaaaagactatcc
Downstream sequence
tttctccactgcattatctttgcacctttgtcaaaagtcaaccggccatatatggggtctatttctgggttctttattctaattcatggatcaaattgtc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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