Basic Information
VIS ID
TVIS44000411
Fusion event
HTLV-1-CLEC16A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
11240049/11146192 (Hg38)
End
11240049/11146192 (Hg38)
Orient
+
Location type
Intronic
Target gene
CLEC16A
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1225/Upstream/5513626; hsa-mir-11401/Downstream/160248;
Nearest TSS
ENST00000527434/Upstream/20182; ENST00000572466/Downstream/49985;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/201286, chr16-CpG: 28/Downstream/27843
Upstream sequence
gtggctctgtccttgcttccttcagatcattcttcagacctcaccatctcagaaggtcttgccagatattctatatagtggcaaccctgtccccactccc
Downstream sequence
agcactccaggggtctctaccttgctcattccttcagagcactcaacctctcctgacattttctactccttgactggccctgccctgtcccatcccatta
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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