Basic Information
VIS ID
TVIS44000420
Fusion event
HTLV-1-CRLF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
18713761/18602951 (Hg38)
End
18713761/18602951 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
CRLF1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-377-3p ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-7155-5p ; hsa-mir-342-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10395/Upstream/216317; hsa-let-7e/Downstream/832112;
Nearest TSS
ENST00000633603/Upstream/4358; ENST00000594859/Downstream/3899;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/7614, chr19-CpG: 189/Downstream/2468
Upstream sequence
tcaccataacctccacacccagctaatttttgtatttttaggagagacggagtttcgccatgttggccaggctggtctcgaactcttgacctccagtgat
Downstream sequence
ccacccgccttggcctcccaaagtgctgggatgacaggcgtgagccactgcacccggccTCAGTGTTTTACTTCTTTGAGCCTCTGGAAAGGGGCTTCTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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