Basic Information
VIS ID
TVIS44000441
Fusion event
HTLV-1-FNIP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
159714936/158793784 (Hg38)
End
159714936/158793784 (Hg38)
Orient
+
Location type
Intronic
Target gene
FNIP2
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-450b-5p ; hsa-mir-3680-3p ; hsa-mir-129-5p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-6797-3p ; hsa-mir-6076
Nearest miRNA
hsa-mir-12113/Upstream/6257268; hsa-mir-1305/Downstream/335018;
Nearest TSS
ENST00000502981/Upstream/24590; ENST00000505445/Downstream/2070;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/24113, chr4-CpG: 149/Downstream/308851
Upstream sequence
GATTCCTCTCAGTTCTGTTTGCATGGGGGTTGTGGAGCTAGGTCAGCTTCCTCCTGACTGTCTTTGAAGTTTCACTGACAATTCTGGACACTCAGATTCC
Downstream sequence
AGCTTTCCAAGCTTTCCTATTGGCCACTGGGTTAGGTTTCATACTCCTTCTATTGGTTGCTGTGATGGGGTTTGTAAATGGAACGGAGGCAAATCATACT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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