Basic Information
VIS ID
TVIS44000453
Fusion event
HTLV-1-OXR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
107762960/106750732 (Hg38)
End
107762960/106750732 (Hg38)
Orient
+
Location type
Intronic
Target gene
OXR1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-200b-3p ; hsa-mir-567 ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-4781-3p ; hsa-mir-144-3p ; hsa-mir-3144-3p ; hsa-mir-3915 ; hsa-mir-6730-3p ; hsa-mir-4689 ; hsa-mir-6858-5p ; hsa-mir-1224-5p ; hsa-mir-3928-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-586 ; hsa-mir-875-5p
Nearest miRNA
hsa-mir-12123/Upstream/2266267; hsa-mir-10400/Downstream/5892761;
Nearest TSS
ENST00000518652/Upstream/10489; ENST00000520037/Downstream/19513;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/92369, chr8-CpG: 92/Downstream/1331895
Upstream sequence
AAATAATTTTTTAATGGAATAGGAGTAAAACAAAATTGTGTCAGTGTGGAAAGGAGTAGGGAAGGATTTGAGAAAATTAATAACTTTAGGGTTGTTAGGT
Downstream sequence
ATTCAAAGTCTCATTTAAATTGTTTTATAACTTAAGGCATAAATATTAACAGATTATTATTTATGTATTGCAGAGGAGAATTTGCGCTTTGGCTTGATGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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