Basic Information
VIS ID
TVIS44000454
Fusion event
HTLV-1-PTP4A3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
142416235/141406135 (Hg38)
End
142416235/141406135 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
PTP4A3
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-495-3p ; hsa-mir-551a
Nearest miRNA
hsa-mir-1204/Upstream/673482; hsa-mir-10400/Downstream/380107;
Nearest TSS
ENST00000518652/Upstream/13561; ENST00000524028/Downstream/15253;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/13741, chr8-CpG: 82/Downstream/11342
Nearby gene
PTP4A3(+15253) ;
Nearest cancer related gene
PTP4A3(OG, No orient, 0)
Upstream sequence
ctttcctgagtgacgcgggcaccactggaggctttgagcggagggggctatgatctgacttaggtcgaggacactggtgggggcagtggtggggataCCC
Downstream sequence
AGGATGCCAGATGGGTATCCCAGATTCTTGGTGACCCTCGGTAGCCCCTCTGGGCGGTGGCTTTAGGCATCTGGGCTCAGGTGTCACCATTTCACTTGTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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