Basic Information
VIS ID
TVIS44000464
Fusion event
HTLV-1-ELAVL4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p33
Reference genome
GRCh37/hg19
Start
50609078/50143406 (Hg38)
End
50609078/50143406 (Hg38)
Orient
-
Location type
Intronic
Target gene
ELAVL4
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-141-3p ; hsa-mir-21-5p ; hsa-mir-510-3p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-340-5p ; hsa-mir-4635 ; hsa-mir-3163 ; hsa-mir-3121-3p ; hsa-mir-548c-3p ; hsa-mir-607 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-643 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-488-5p ; hsa-mir-10b-3p
Nearest miRNA
hsa-mir-12136/Upstream/5597854; hsa-mir-101-1/Downstream/916431;
Nearest TSS
ENST00000473358/Upstream/33590; ENST00000492299/Downstream/1547;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/94758, chr1-CpG: 86/Downstream/189589
Upstream sequence
GTAATAATAATGGAAGCTACTagttatcagatgtctgctatgccttggtttcctcatctataagacatagagaatattagaatatgcttcattgccttct
Downstream sequence
tgtgaggagacagtgagagaagtcacattggatgattggcagagtaactaataaacatcagtgattgtggttatgtgcccaccactgttctggtgcttta
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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