Basic Information
VIS ID
TVIS44000468
Fusion event
HTLV-1-CUBN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
17006861/16964862 (Hg38)
End
17006861/16964862 (Hg38)
Orient
-
Location type
Intronic
Target gene
CUBN
miRNAs that regulate target gene
hsa-mir-5590-5p ; hsa-mir-607 ; hsa-mir-130b-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3135b ; hsa-mir-140-5p ; hsa-mir-4760-3p
Nearest miRNA
hsa-mir-1265/Upstream/2528201; hsa-mir-107/Downstream/880245;
Nearest TSS
ENST00000439456/Upstream/147334; ENST00000497849/Downstream/19333;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/146886, chr10-CpG: 49/Downstream/236443
Upstream sequence
CTTGCTGCCGCCAGGAATGTATCAAGTTTAATGGACGTGGCTTCTGTTTTAAGATCTCCAAAGCATCTGTTCATTGCCTAATATCTACAACTGTGCCCCA
Downstream sequence
GTCCTCTCCCCTAAGCCCTAGGCTTGTATAGACAACTGTATCGTAGACATCATCTCTTCCATGTTCCACAAACCCCGAAAATCAGTGTCTCAAACTGAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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