Basic Information
VIS ID
TVIS44000469
Fusion event
HTLV-1-PLXDC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.31
Reference genome
GRCh37/hg19
Start
20514161/20225232 (Hg38)
End
20514161/20225232 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLXDC2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-1-3p ; hsa-mir-181a-5p ; hsa-let-7b-5p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-3152-3p ; hsa-mir-4635 ; hsa-mir-4694-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-599 ; hsa-mir-3912-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6755-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-198 ; hsa-mir-193a-5p ; hsa-mir-1273f ; hsa-mir-1304-3p ; hsa-mir-4781-3p ; hsa-mir-5011-5p ; hsa-mir-3976 ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-302f ; hsa-mir-3675-3p ; hsa-mir-136-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3622b-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-103b ; hsa-mir-5693 ; hsa-mir-7705 ; hsa-mir-617 ; hsa-mir-3605-3p ; hsa-mir-8087 ; hsa-mir-6854-5p ; hsa-mir-6885-3p ; hsa-mir-147a ; hsa-mir-5010-3p ; hsa-mir-6818-5p
Nearest miRNA
hsa-mir-1265/Upstream/2380039; hsa-mir-107/Downstream/326738;
Nearest TSS
ENST00000439456/Upstream/133448; ENST00000417845/Downstream/590593;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/407215, chr10-CpG: 149/Downstream/947967
Upstream sequence
ATTTCTGTTGCATTTAGCTTTCTATTTCTGAAGATATCATAAGAATTTTCATCCCGAGATAAAATTTTAGAACATTATTCTGCCTTTTTCCTGGAATACT
Downstream sequence
TCTAAGCTTATATTTTTATTACCAAGTCTGTAGTGATAGATCAAGTGTCTAGTCATTTGTCATTCAGTCAAATTATTTTTTGACTTTCATACATAAATCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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