Basic Information
VIS ID
TVIS44000480
Fusion event
HTLV-1-TALDO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
755987/755987 (Hg38)
End
755987/755987 (Hg38)
Orient
-
Location type
Exonic
Target gene
TALDO1
miRNAs that regulate target gene
hsa-mir-935 ; hsa-mir-378a-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-210/Upstream/187789; hsa-let-7a-2/Downstream/500618;
Nearest TSS
ENST00000527297/Upstream/243; ENST00000530666/Downstream/7995;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/7955, chr11-CpG: 20/Downstream/7205
Nearest cancer related gene
TALDO1(OG, No orient, 0)
Upstream sequence
AGTACAAGCCCCAGGATGCTACCACCAACCCGTCCCTGATCCTGGCCGCAGCACAGATGCCCGCTTACCAGGAGCTGGTGGAGGAGGCGATTGCCTATGG
Downstream sequence
CCGGAAGCTGGGCGGGTGAGTGCCTGGACTCGGGAGGGTCCCAGCTAGGCCCTCGTGCTAGTCTAGTTGGCCTTGCTTCCCTCCCTAACTGAATTTTAGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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