Basic Information
VIS ID
TVIS44000482
Fusion event
HTLV-1-PDE2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
72379219/72668175 (Hg38)
End
72379219/72668175 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PDE2A
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-335-5p ; hsa-let-7d-3p ; hsa-mir-3619-3p ; hsa-mir-4690-3p ; hsa-mir-5685
Nearest miRNA
hsa-mir-10392/Upstream/53045; hsa-let-7a-2/Downstream/115355;
Nearest TSS
ENST00000527297/Upstream/10054; ENST00000542022/Downstream/889;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/24861, chr11-CpG: 39/Downstream/28830
Upstream sequence
AACCCTTGGGTGGATCCTGGTGGGCCACAACACAAAGTCCAAACTCTCAGCCTGGAATCAGCAGCTCTCTGCTCAGCTGTTCCTCTGCCGAGATGTCTCA
Downstream sequence
CATCCAACTTTAGTTGTCCACATCTTGCCTGTCTGCCATCTGGAACAgtaatgtatggaaagagcaggagctctggaagcagacagatttgtgccccagg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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