Basic Information
VIS ID
TVIS44000497
Fusion event
HTLV-1-ADAM10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
58906246/58614047 (Hg38)
End
58906246/58614047 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAM10
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-155-5p ; hsa-mir-484 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-451a ; hsa-mir-103a-3p ; hsa-mir-448 ; hsa-mir-655-3p ; hsa-mir-449a
Nearest miRNA
hsa-mir-10393/Upstream/3241013; hsa-mir-11181/Downstream/557136;
Nearest TSS
ENST00000557528/Upstream/26540; ENST00000559745/Downstream/7457;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/547469, chr15-CpG: 125/Downstream/134835
Upstream sequence
tctgcaaCCAATCAATCAATCACTTAAAAGCTACAGAAGGAGAAGAGATTTAAAAAGGCACAGAAAACCTTTGTTTTGGCTGgggtgcactggctcacac
Downstream sequence
ctgtaatcccaacactttgggaggccaaagcaggtggatcacttgtcaggagcttgaaaccccgtctctactaaaaatacgaaaaaaactagctgggcat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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