Basic Information
VIS ID
TVIS44000499
Fusion event
HTLV-1-RNF166 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
88770678/88704270 (Hg38)
End
88770678/88704270 (Hg38)
Orient
-
Location type
Intronic
Target gene
RNF166
miRNAs that regulate target gene
hsa-mir-7977 ; hsa-mir-6820-5p ; hsa-mir-4660 ; hsa-mir-6736-3p
Nearest miRNA
hsa-mir-11401/Upstream/235239; hsa-mir-4722/Downstream/12008;
Nearest TSS
ENST00000527434/Upstream/653; ENST00000565071/Downstream/1992;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5279, chr16-CpG: 125/Downstream/1559
Upstream sequence
AGCAACAAACTTCCGAAGGGAACCTGAAGAGCCTTTAAACTTTCTGTGGTCATTTGCATGCATGCCTTAGCAACACCAACAAGAAACAAAGTTAGAAGCA
Downstream sequence
GAGAGAGAACAGCCAGAAAACAAAAGCCAGCAGGAAAAGTCGGGGAGAAAAATCTTTGAAAGGCAAAGGCTGTGTGAAAAGCTCTTGCAGGACCCGCGGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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