Basic Information
VIS ID
TVIS44000500
Fusion event
HTLV-1-FBXL16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
745525/695525 (Hg38)
End
745525/695525 (Hg38)
Orient
-
Location type
Exonic
Target gene
FBXL16
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-149-5p ; hsa-mir-1185-1-3p ; hsa-mir-544a ; hsa-mir-1185-2-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-6794-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-1304-3p ; hsa-mir-4639-3p ; hsa-mir-4709-5p ; hsa-mir-421 ; hsa-mir-8057 ; hsa-mir-3191-5p ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-760 ; hsa-mir-6822-3p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-4272 ; hsa-mir-25-5p ; hsa-mir-3141 ; hsa-mir-4467 ; hsa-mir-4730 ; hsa-mir-658
Nearest miRNA
hsa-mir-3176/Upstream/152159; hsa-mir-11401/Downstream/74658;
Nearest TSS
ENST00000527434/Upstream/262; ENST00000570132/Downstream/7;
Nearest CpG islands
chr16-CpG: 171/Target, None/Upstream, None/Downstream
Upstream sequence
GAGCTCCTCTAGGCGGTGCAGGTCGCAGGCCACGTACTCCAGCGCCATGTCGGTGATGCGTGGGCACCACGAGAGGTCAAGGCTGCGCAGCTTGCGCAGG
Downstream sequence
TTCTCGGCCACGAGCTCCACGCCGTCGTCGGTGACCTTGGAGCAGCCCGAGAGGCTGAGCGCGGTGAGGTTGGGCAGGCTGTGCACCACGTTGACCACGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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