Basic Information
VIS ID
TVIS44000504
Fusion event
HTLV-1-SEZ6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
27318861/28991843 (Hg38)
End
27318861/28991843 (Hg38)
Orient
-
Location type
Intronic
Target gene
SEZ6
miRNAs that regulate target gene
hsa-mir-2117 ; hsa-mir-3191-5p ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-4261 ; hsa-mir-4273 ; hsa-mir-4445-5p ; hsa-mir-4496 ; hsa-mir-4677-5p ; hsa-mir-518c-5p ; hsa-mir-651-3p ; hsa-mir-6739-3p ; hsa-mir-6764-3p ; hsa-mir-6824-3p ; hsa-mir-7156-5p
Nearest miRNA
hsa-mir-1180/Upstream/130113; hsa-mir-10226/Downstream/398819;
Nearest TSS
ENST00000595228/Upstream/9971; ENST00000466889/Downstream/14070;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/5578, chr17-CpG: 94/Downstream/13407
Upstream sequence
AGAAAGGCCTCGGGGAACTGGGCGTAGCAGCTACTCATTCCTCAGGGAGGATTCTTGTCATCCACCGATGAGGTTTGCTTCCCAAACTTGGCCGCGCACA
Downstream sequence
GGTGCTCTGAGGGTTGGATGTATGATGGGCAATTCTGGAAGCTCAGAGCCAGTTTAGGAGGATTTTATGGGTGGAGGACAGCCAGGAACACTTAGCTTCG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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