Basic Information
VIS ID
TVIS44000512
Fusion event
HTLV-1-FLT3LG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
49985029/49481772 (Hg38)
End
49985029/49481772 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
FLT3LG
Nearest miRNA
hsa-mir-10395/Upstream/172904; hsa-let-7e/Downstream/19013;
Nearest TSS
ENST00000633603/Upstream/2855; ENST00000486930/Downstream/5782;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/17178, chr19-CpG: 51/Downstream/5406
Upstream sequence
CTCATGTGGGGCTGGCTTGCTTGCtttatttttttttgagatggactctcactctgtcacccaggctggagtgcagtggcgggatcttggctcactgcaa
Downstream sequence
cctccacctcccaggttcaagcaattctcctgcctcagcctcccaagtagctgggattacaggcgcccgccaccatgcctggctaattttttgtattttt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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