Basic Information
VIS ID
TVIS44000514
Fusion event
HTLV-1-NRXN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
50619626/50392488 (Hg38)
End
50619626/50392488 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
NRXN1
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-16-5p ; hsa-mir-616-5p ; hsa-mir-498 ; hsa-mir-1537-5p ; hsa-mir-302a-5p ; hsa-mir-3607-3p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-574-5p ; hsa-mir-4752 ; hsa-mir-6867-5p ; hsa-mir-8056 ; hsa-mir-3691-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-7114-5p ; hsa-mir-6818-5p ; hsa-mir-4320
Nearest miRNA
hsa-mir-1301/Upstream/1332830; hsa-mir-10b/Downstream/303684;
Nearest TSS
ENST00000437798/Upstream/44692; ENST00000634985/Downstream/24767;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/44809, chr2-CpG: 96/Downstream/634989
Upstream sequence
GTTTTGATAGCCCTGACTGTAAAACATTGCCAGATGATAGGATCATAGAAGAGGAATAGAAATGTCAATGCATTTAAGTCATGAGAAGGTGCCTTAGACT
Downstream sequence
GCAATAGGTAAGGTGAAAAAGAGATGTCTTTTACAAAGATATGCAAATATTAAATATCATAAATCAGTTCTAAATTTTGAGCTAAACTCTCAGACCAGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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