Basic Information
VIS ID
TVIS44000538
Fusion event
HTLV-1-KCNH8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
19228539/19187047 (Hg38)
End
19228539/19187047 (Hg38)
Orient
-
Location type
Intronic
Target gene
KCNH8
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12127/Upstream/2253787; hsa-let-7g/Downstream/127801;
Nearest TSS
ENST00000440867/Upstream/38513; ENST00000475063/Downstream/160674;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/38439, chr3-CpG: 87/Downstream/759794
Upstream sequence
cccattcaattcagctgttgtagcatgaaagcagccatagataatacataaacaaatgggcataattatgtcagaataaaactttatttatggacattgg
Downstream sequence
aattcaaatttcatattattttcatgttacaaaatgttgttctttttgtttttttggttttcaaccacttaaaaatctaagactagtccctgctgtgaac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate