Basic Information
VIS ID
TVIS44000549
Fusion event
HTLV-1-HPGD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
GRCh37/hg19
Start
175411670/174490519 (Hg38)
End
175411670/174490519 (Hg38)
Orient
-
Location type
UTR3
Target gene
HPGD
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-587 ; hsa-mir-4742-3p ; hsa-mir-486-5p ; hsa-mir-4289 ; hsa-mir-664a-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-12113/Upstream/66655; hsa-mir-1305/Downstream/7678774;
Nearest TSS
ENST00000502981/Upstream/114074; ENST00000507483/Downstream/2942;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/206275, chr4-CpG: 53/Downstream/31736
Nearest cancer related gene
HPGD(TSG, No orient, 0)
Upstream sequence
TCCATAAATGAAAAGGTTATACTATTTACACGACAGAGGAAAAATACAGAAGATAAGTGATACTGGGCAAACCGACATCATTTACTGATTAGTCACTGCC
Downstream sequence
AGAACATACAAACAAGCTTATGCCTGATTACAGTTTATCTCTATCAGATGTTCATTGATGTTCACTACTTTGTCTTTAATACATTATATGAAAATCTAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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