Basic Information
VIS ID
TVIS44000557
Fusion event
HTLV-1-BTBD9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
38382238/38414462 (Hg38)
End
38382238/38414462 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
BTBD9
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30e-5p ; hsa-mir-149-5p ; hsa-mir-26a-5p ; hsa-let-7b-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-5692a ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-6731-5p ; hsa-mir-8085 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-4719 ; hsa-mir-1178-3p ; hsa-mir-369-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6781-5p ; hsa-mir-4268 ; hsa-mir-4660 ; hsa-mir-766-3p ; hsa-mir-7112-5p ; hsa-mir-338-3p ; hsa-mir-4530 ; hsa-mir-3918 ; hsa-mir-6736-3p ; hsa-mir-3065-3p ; hsa-mir-6871-3p ; hsa-mir-6749-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-600 ; hsa-mir-2116-3p ; hsa-mir-5193 ; hsa-mir-4700-3p ; hsa-mir-374c-5p ; hsa-mir-4643 ; hsa-mir-466 ; hsa-mir-4789-3p ; hsa-mir-655-3p
Nearest miRNA
hsa-mir-1236/Upstream/859040; hsa-mir-10398/Downstream/659852;
Nearest TSS
ENST00000381078/Upstream/271465; ENST00000412822/Downstream/67230;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/594688, chr6-CpG: 77/Downstream/224967
Upstream sequence
aatagctaatagtggctctcccaataaattttactcattctctgaataatgaaggatgtaagtcacaaggccctgatgatttgaattcatcatttttCCC
Downstream sequence
CCAACCATATATTATTTTTTAAAAACAACCAACAGAAAGACCCTTTTCTCCCTCTGGCTACTGCCCTTTCTCCTTTTTTCTTTTTCCTTCACATCAATCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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