Basic Information
VIS ID
TVIS44000559
Fusion event
HTLV-1-IMPG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
76689755/75980038 (Hg38)
End
76689755/75980038 (Hg38)
Orient
-
Location type
Intronic
Target gene
IMPG1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6733-3p ; hsa-mir-1231 ; hsa-mir-5706 ; hsa-mir-4782-5p ; hsa-mir-1290 ; hsa-mir-876-5p ; hsa-mir-3167 ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-6839-5p ; hsa-mir-378j ; hsa-mir-5581-3p ; hsa-mir-670-3p ; hsa-mir-617
Nearest miRNA
hsa-mir-10398/Upstream/551565; hsa-mir-10524/Downstream/2559225;
Nearest TSS
ENST00000381078/Upstream/44989; ENST00000626131/Downstream/92640;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/230488, chr6-CpG: 132/Downstream/1482476
Upstream sequence
CAAAGTATTTGAAATAAGAAAAAGCAGATTGAAAAAAGGATGAGAAATGAAAATCTGATTCCACACTGTATTGTATTGGGGGATTAGCTACTCGGGTACC
Downstream sequence
ACCTGAAGAGTAGGTCTGATCAACTATGCCTAATATGCTTCAAGCAGGATCGTTTCGGACATGATCACACACTTACGGAATGGTGGATATTTAAAAAGAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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