Basic Information
VIS ID
TVIS44000565
Fusion event
HTLV-1-IMMP2L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
110728338/111088282 (Hg38)
End
110728338/111088282 (Hg38)
Orient
-
Location type
Intronic
Target gene
IMMP2L
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-587 ; hsa-mir-3180-5p ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-6815-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-103a-2-5p ; hsa-mir-3188 ; hsa-mir-770-5p ; hsa-mir-4712-5p
Nearest miRNA
hsa-mir-10525/Upstream/8616751; hsa-mir-10399/Downstream/3565063;
Nearest TSS
ENST00000635602/Upstream/124717; ENST00000464835/Downstream/2724;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2517820, chr7-CpG: 68/Downstream/473741
Upstream sequence
CCCAACCACTAAGTCAGTGAATATCTACTGTACCCAATATTTTCTTATTTGATGATGAAGGCAAAACTCTTTCAGTATAATTTAAGGGTTGTAATTATTC
Downstream sequence
ATTTACATTTTAAAACCATTTCAATACATTTCCATTAAAACTCAGTATTCATCTAGGAAACCCTGTAGACATTTCCTACAATGTAGGTAACATGTACAAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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