Basic Information
VIS ID
TVIS44000584
Fusion event
HTLV-1-DAB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
GRCh37/hg19
Start
57826833/57361161 (Hg38)
End
57826833/57361161 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
DAB1
Nearest miRNA
hsa-mir-12136/Upstream/2135438; hsa-mir-101-1/Downstream/2372066;
Nearest TSS
ENST00000473358/Upstream/53797; ENST00000422038/Downstream/25415;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/715597, chr1-CpG: 222/Downstream/61130
Upstream sequence
gggaacagaggacaccacagaacactgagaaatggcatccctcctagcctaagaaaaacaagtaaagctttcAGACAAAAAAATAAAGAGCATTAGGTAG
Downstream sequence
TATTGAAAGAAGAAACTGCAATTACAGATGTAATATCAAATACTGAGTCACAAATACATGAATGTACTCAGTGTCTGGATGAATGACATAAAACTCAGCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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