Basic Information
VIS ID
TVIS44000601
Fusion event
HTLV-1-FADS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
61618865/61851393 (Hg38)
End
61618865/61851393 (Hg38)
Orient
+
Location type
Intronic
Target gene
FADS2
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-18a-3p ; hsa-mir-500a-3p ; hsa-mir-423-3p ; hsa-mir-324-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-129-2/Upstream/36153; hsa-let-7a-2/Downstream/26823;
Nearest TSS
ENST00000527297/Upstream/3229; ENST00000522359/Downstream/2794;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/22155, chr11-CpG: 101/Downstream/39704
Upstream sequence
CTTTCTTGTGCGTGGTGGCCAGAGAAGCCTCTCCTTTCCCGACATCTTCTCACCCCCGACACTTCTGGAACGCTGGCTTTGGGGCAGGAGATAGGGGTGG
Downstream sequence
GAGGCTGTGAGGATCTGGTTGTTCAGTTACCAGCGGCGTTTGGAAGTCCCCAGCCAGTGCCGCGGTGTTCTGTGGAAATCCCCGCTCTCACACTCATGGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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